Sulphonylureas and hypoglycaemia

Sulphonylureas and hypoglycaemia.

Risk of hypoglycaemia in users of sulphonylureas compared with metformin in relation to renal function and sulphonylurea metabolite group: population based cohort study

OBJECTIVE  To determine the association between use of sulphonylureas and risk of hypoglycaemia in relation to renal function and sulphonylurea metabolic group compared with use of metformin. DESIGN  Population based cohort study using routinely collected data from general practices in England. SETTING  Clinical Practice Research Datalink (CPRD) database, 2004-12. PARTICIPANTS  120 803 ne...

Artefactual hypoglycaemia: and audit.

CORRESPONDENCE Paradoxical severe decrease in serum HDL-cholesterol after treatment with a fibrate: reply by the authors We read the letter of Olukoga 1 (in response to our earlier paper 2) with interest and feel that it covers the area of fibrate induced hy-poalphalipoproteinaemia excellently. Unfortunately , we are not aware of a clear and unifying explanation as to why some patients exhibit ...

Falciparum malaria and hypoglycaemia.

Sir, I read with interest the case report of Shalev et al.} on falciparum malaria-induced hypoglycaemia, and I wish to suggest another possible and important mechanism in the pathogenesis of hypoglycaemia associated with falciparum malaria infection. Several recent studies have demonstrated elevated serum levels of tumour necrosis factor-a (TNF) in patients with falciparum malaria,2-6 where thi...

Hypoglycaemia and cerebral malaria.

A patient with severe hypoglycaemia complicating cerebral malaria is reported. No other recognized cause of hypoglycaemia was detected during life or at autopsy. This case adds to the existing evidence that, through several possible mechanisms, cerebral malaria can give rise to life-threatening hypoglycaemia.